What, Why and How cannabis microdosing ?

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November 30, 2021

What is micro-dosing of cannabis ?

Microdosing of cannabis (CBD and THC) works on the principle that less is more. It’s the science of finding the smallest possible therapeutic dose while effectively producing health benefits.

Why microdosing could be the future of medical cannabis ?

Using cannabis produces an amazing array of benefits that stimulate our creativity, allow us to relax or help us fall asleep without any problems.
And people who need CBD don’t especially have to take any action, considering its non-psychoactive effect.

But for patients who need THC for medical purposes, the goals are very different. The goal is not to experience the psychoactive effects produced by THC, but rather to relieve and/or alleviate the symptoms associated with certain medical conditions. Therefore, the micro-dosing of THC combined with CBD is interesting in the field of cannabis for medical purposes.

Micro-dosing is beneficial for those who simply want to alleviate certain health issues without disruptive side effects. For example, patients struggling with mood disorders, sleep disorders and the like, may benefit from consuming small amounts of cannabis daily, or even in 2-3 day cycles, which can help prevent tolerance from developing.
The theory is that micro-dosing can provide relief long before psychoactive symptoms such as paranoia, cravings, lethargy and others begin to appear.
The practice requires more precise dosing to find the sweet spot and includes increasing doses in small increments until the person begins to feel different. At that point, the person’s tolerance threshold is reached.

Ingestion of cannabis through oil is the easiest way to treat oneself because the doses can be properly measured. Ingestion also offers a longer therapeutic period per dose.

Dr. Allan Frankel, an internist in Los Angeles, is one of the leading proponents of microdosing.
A quarter of my patients take less than 3 mg of THC per day. In all medicine, with all drugs, you’re looking for the minimum effective dose. Period.
Cannabis Pharmacy author Michael Backes told Rolling Stone, “When prohibition ends, microdosing could be the most popular way to use cannabis.”

Why does this make sense ?

Patients with chronic conditions (pain, depression, etc.) already often microdose simply with prescription medications. Patients who take pills 2-3 times a day do so to temporarily calm discomfort.
But these medications often come with debilitating side effects, whereas finding one’s sweet spot through cannabis microdosing can quickly improve mood or relieve pain while allowing the user to maintain their normal state of mind.

Ultimately, microdosing may be the future of cannabis medicine for patients who want the benefits of cannabis but want to avoid its intoxicating effects.

Some interesting dosage advices :

Preparations, galenic forms, manufacturers, dosage and costs

  • The effects depend on the dosage and the application and vary greatly from person to person. In older patients, a lower dosage is often already effective.
  • Non-responder rate: approx. 30

Dosage / Onset of effects

  • Oral: to be taken after a meal with a fatty substance (e.g. olive oil on bread) -> onset of action: after 1 – 3 hours.
  • Sublingual: keep in the mouth as long as possible, or chew for a long time with olive oil on bread -> effects appear after 2 – 20 minutes
  • The evening dosage is usually sufficient; in case of spasticity: 1 – 3 times / day and possibly 1 time / night

Target dosage for certain indications (experience from practice)

  • Neuropathic pain: 4 – 20 mg THC / day
  • Muscle pain, muscle cramps resistant to treatment: 4 – 30 mg THC / day
  • Fibromyalgia (in about 50% of cases, improvement / reduction of symptoms): 5 – 20 mg THC / day
  • Spasticity: 10 – 50 mg THC / day (maximum known dosage: 230 mg THC / day, without psychoactive side effects)
  • Headache: 3 – 10 mg THC / day
  • Nausea, cachexia: 4 – 15 mg THC / day

Sources:

https://www.praxis-suchtmedizin.ch/praxis-suchtmedizin/images/stories/cannabinoide/290200921_FR_Praeparate-galenik-hersteller-dosierung-kosten.pdf

https://www.praxis-suchtmedizin.ch/praxis-suchtmedizin/index.php/fr/cannabis/les-cannabinoides-en-medecine/preparations-formes-galeniques-fabricants-dosage-et-couts

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